The goal of orthomolecular medicine is to restore the body's optimal environment by correcting imbalances or deficiencies based on individual biochemistry by using natural substances such as vitamins, minerals, trace elements and amino acids.

[122], Advocates of orthomolecular medicine, including Pauling, Hoffer and Ewan Cameron have claimed that their findings are actively suppressed by the medical and pharmaceutical industry. Amongst the individuals described posthumously as orthomolecularists are Max Gerson, who developed a diet that he claimed could treat diseases, which the American Medical Association's 1949 Council on Pharmacy and Chemistry found ineffective;[23] and the Shute brothers, who attempted to treat heart disease with vitamin E.[24] Several concepts now cited by orthomolecularists, including individual biochemical variation[13] and inborn errors of metabolism,[21][25][26] debuted in scientific papers early in the 20th century. [121] Rath's trials, conducted with the aid of AIDS denialist David Rasnick, were declared unlawful by the Cape High Court; Rath, Rasnick and their foundation were barred from conducting further unauthorised clinical trials and from advertising their products. Conditions for which orthomolecular practitioners have claimed some efficacy are: acne,[40] alcoholism,[41] allergies, arthritis, autism, bee stings, bipolar disorder, burns, cancer,[42][43] the common cold, depression, drug addiction, drug overdose, epilepsy, heart diseases, heavy metal toxicity, acute hepatitis, herpes, hyperactivity, hypertension, hypoglycemia, influenza, learning disabilities, mental and metabolic disorders,[44] migraine, mononucleosis, mushroom poisoning, neuropathy & polyneuritis (including multiple sclerosis), osteoporosis,[45] polio, a hypothesised condition called "pyroluria", radiation sickness, Raynaud's disease, mental retardation, schizophrenia,[4] shock, skin problems, snakebite, spider bite, tetanus toxin and viral pneumonia. This website is managed by Riordan Clinic © (Riordan Clinic) 2004 - 2017 Randomised, placebo-controlled trial", "Long-term Use of β-Carotene, Retinol, Lycopene, and Lutein Supplements and Lung Cancer Risk: Results From the VITamins And Lifestyle (VITAL) Study", "Extra Vitamin E: No Benefit, Maybe Harm", "The science and humanism of Linus Pauling (1901–1994)", "Hidden in plain sight: the pioneering work of Frederick Robert Klenner, M.D", "Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice", Proceedings of the National Academy of Sciences of the United States of America, "Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs", "The dark side of Linus Pauling's legacy", "Clinical data shows vitamin C may reduce risks of cancer, heart disease and variety of other health disorders", "A stone that kills two birds: how pantothenic acid unveils the mysteries of acne vulgaris and obesity", "Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer", "Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology", "Complementary and alternative medicine use among adults: United States, 2002", "The safety of vitamins and diet supplements", "Alternative (complementary) medicine: a cuckoo in the nest of empiricist reed warblers", "Propagation of the Absurd: demarcation of the Absurd revisited", "Report on complementary and alternative medicine", "Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discoveries", "Megavitamin and megamineral therapy in childhood. CS1 maint: multiple names: authors list (, National Center for Complementary and Integrative Health, National Center for Complementary and Alternative Medicine, "Gale encyclopedia of alternative medicine: holistic medicine", "Orthomolecular Medicine and Megavitamin Therapy: Future and Philosophy", The Theory?
As Abram Hoffer wrote: Other members of the medical community deny the existence of such an institutional prejudice.
[17][18][19] The scientific consensus view is that for normal individuals, a balanced diet contains all necessary vitamins and minerals and that routine supplementation is not necessary outside of specific diagnosed deficiencies.[20]. Images from Wikimedia Commons / Public domain. [113][114], Matthias Rath has been extensively criticized for presenting his vitamin supplements as a treatment for AIDS and for testing them in illegal trials in South Africa. A study using 250 mg and 1000 mg doses of vitamin C along with other antioxidants to treat people with AIDS did not find any benefit.

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